Te blood pressure during shock and shocklike states. Phenylephrine is ready in concentrated stock vials that demand further dilution before administration. This study evaluated the physical and chemical stability of phenylephrine in extemporaneously prepared polyvinyl chloride (PVC) bags. Techniques: Phenylephrine HCl 10 mg/mL answer was diluted with 0.9 sodium chloride for injection to final concentrations of 200 g/mL and 400 g/mL and stored at room temperature (23 -25 ) exposed to fluorescent light. Stability of phenylephrine HCl was evaluated by highperformance liquid chromatography on days 0, 7, 14, 21, 30, 45, and 60. Results: Phenylephrine HCl 200 and 400 g/mL solutions in PVC bags were physically stable for the duration of the whole 60-day study period. Phenylephrine HCl retained 95 with the original concentration. Conclusion: Phenylephrine HCl diluted to 200 or 400 g/mL with 0.9 sodium chloride for injection is each physically and chemically stable for any period of 60 days with 5 degradation when stored at area temperature and exposed to fluorescent lighting. Key Words–alpha-1-adrenergic agonist, HPLC, neosynephrine, phenylephrine, stability, vasopressor Hosp Pharm–2014;49(five):455?Phenylephrine can be a synthetic sympathomimetic agent employed to preserve sufficient blood stress for the duration of anesthesia also as treat vascular failure in shock and shocklike states.1 Phenylephrine may be administered as an intravenous bolus or continuous intravenous infusion. Phenylephrine is prepared in concentrated stock vials that demand additional dilution before administration. Our institution typically prepares infusions by adding phenylephrine 50 mg, 100 mg, or 200 mg to 250 mL of 0.9 sodium chloride for injection. Preceding stability studies have shown phenylephrine to become stable for 14 days at room temperature when diluted to 100 and 200 g/mL in sodium chloride 0.9 in polyvinyl chloride (PVC) bags.two Having said that, no research have evaluated the stability of phenylephrine stored in PVC bags for provided that 60 days.*The goal of this study was to ascertain the physical and chemical stability of phenylephrine diluted to 200 and 400 g/mL in sodium chloride 0.1919022-57-3 Data Sheet 9 PVC bags when stored at area temperature though exposed to typical fluorescent lighting.Buy90396-00-2 Stability of your diluted phenylephrine solutions was evaluated over a 60-day period.PMID:24631563 Methods Sample Preparation Dilution of phenylephrine hydrochloridea to 200 and 400 g/mL was performed by the University of Colorado Hospital Pharmacy beneath aseptic method by adding either 50 or one hundred mg of phenylephrine to 250 mL sodium chloride 0.9 PVC bagsb. The bags had been then stored at room temperature (23 -25 ) below standard fluorescent lighting. 3 bags for eachClinical Specialist, Sterile Compounding, Acute Care Pharmacy Manager, Division of Pharmacy, University of Colorado Hospital, Aurora, Colorado; Department of Clinical Pharmacy, University of Colorado Skaggs College of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado. Corresponding author: Josiah J. Jansen, PharmD, Clinical Specialist, Sterile Compounding, Division of Pharmacy, University of Colorado Hospital, 12605 E. 16th Avenue, Aurora, CO 80045; telephone: 720-8481389; fax: 720-848-4190; e-mail: [email protected] PharmacyStability of Phenylephrine in PVC Bagsconcentration had been assessed for physical and chemical stability more than a total period of 60 days. Stabilities were assessed on days 0, 7, 14, 21, 30, 45, and 60. Physical Evaluation Physical stabi.